TABLE 2

Drug Liking VAS E_max and E_min following oral or intranasal drug administration (PD analysis sets)

Oral Administration
Parameter	Statistic	PBO  (n = 37)	OXY IR 30 mg  (n = 37)	OXY IR 60 mg  (n = 37)	ELX 100 mg  (n = 35)	ELX 300 mg  (n = 36)	ELX 1000 mg  (n = 35)
Drug Liking VAS E_max	Mean (S.D.)	54.3 (9.5)	85.8 (14.3)	90.9 (11.5)	56.8 (13.7)	58.7 (13.4)	60.0 (14.8)
	Median	51.0	88.0	100.0	51.0	51.5	51.0
	Median difference (IQR)
	versus PBO	—	34.5 (23.5, 45.5) ***	41.0 (25.0, 49.0) ***	0.0 (–1.0, 1.0)	0.0 (0.0, 9.0) ^*	0.0 (0.0, 12.0) ^*
	versus OXY IR 30 mg	—	—	—	−35.0 (–45.0, –24.0) ***	−31.0 (–43.0, –17.0) **	−33.0 (–45.0, –16.0) **
	versus OXY IR 60 mg	—	—	—	−37.0 (–49.0, –26.0) ***	−33.0 (–49.0, –20.0) ***	−35.0 (–49.0, –21.0) ***
Drug Liking VAS E_min	Mean (S.D.)	46.5 (11.8)	48.6 (5.8)	42.5 (15.0)	45.0 (14.2)	44.9 (11.1)	38.3 (19.6)
	Median	50.0	50.0	50.0	50.0	50.0	50.0
	Median difference (IQR)
	versus PBO	—	0.0 (0.0, 0.0)	0.0 (–1.0, 0.0)	0.0 (–1.0, 0.0)	0.0 (–2.0, 0.0)	0.0 (–14.0, 0.0) **
	versus OXY IR 30 mg	—	—	—	0.0 (–1.0, 0.0) ^*	0.0 (–2.0, 0.0) ^*	0.0 (–16.0, 0.0) **
	versus OXY IR 60 mg	—	—	—	0.0 (–1.0, 0.0)	0.0 (–1.0, 0.0)	0.0 (–16.0, 0.0)
Intranasal Administration
Parameter	Statistic	PBO lactose  (n = 32)	PBO ELX  (n = 34)	OXY IR 15 mg  (n = 32)	OXY IR 30 mg  (n = 32)	ELX 100 mg  (n = 32)	ELX 200 mg  (n = 32)
Drug Liking VAS E_max	Mean (S.D.)	49.1 (9.0)	52.2 (9.1)	79.5 (22.0)	88.7 (14.6)	53.2 (21.7)	54.9 (21.0)
	Median	51.0	51.0	81.0	95.0	51.0	51.0
	Median difference (IQR)
	versus PBO lactose	—	0.0 (0.0, 0.0)	36.0 (16.5, 49.0) ***	47.0 (28.0, 49.0) ***	0.0 (–1.0, 2.0)	0.0 (–1.0, 20.0)
	versus PBO ELX	—	—	—	—	0.0 (–1.0, 1.0)	0.0 (0.0, 12.0)
	versus OXY IR 15 mg	—	—	—	—	−28.0 (–48.0, -12.0) ***	−26.0 (–48.0, -9.0) ***
	versus OXY IR 30 mg	—	—	—	—	−45.0 (–49.0, -26.0) ***	−42.0 (–49.0, -11.0) ***
Drug Liking VAS E_min	Mean (S.D.)	45.3 (14.3)	38.1 (19.2)	48.1 (16.3)	45.6 (16.9)	16.4 (21.7)	12.4 (20.1)
	Median	50.0	49.0	50.0	50.0	0.0	0.0
	LS mean difference (S.E.)
	versus PBO lactose	—	−6.7 (4.1)	2.7 (4.2)	0.1 (4.2)	−28.4 (4.2) ***	−33.0 (4.20) ***
	versus PBO ELX	—	—	—	—	−21.7 (4.1) ***	−26.3 (4.1) ***
	versus OXY IR 15 mg	—	—	—	—	−31.1 (4.2) ***	−35.7 (4.2) ***
	versus OXY IR 30 mg	—	—	—	—	−28.5 (4.2) ***	−33.1 (4.2) ***

ELX, eluxadoline; IQR, interquartile range; OXY IR, oxycodone immediate release; PBO, placebo.
↵* P < 0.05, **P < 0.01, and ***P < 0.0001.