TABLE 1

Experimental groups and reports of ANOVA analysis

Behavioral TestMouse StrainNo. of MiceDrugs (Route)Main Effects and Interactions after ANOVA Analysis
CohortF ValueP Value
PPIC57Bl/6JVehicle and MK-801 controls, 15–17; others, 9–10BQCA (s.c.) + antipsychotics (i.p.)MK-801 overallF(1, 343) = 315.3<0.001
BQCA aloneNone
BQCA + haloperidol
 BQCA effect F(4, 174) = 4.30.002
 Haloperidol effectF(1, 174) = 45.0<0.001
 BQCA × haloperidol interactionF(4, 174) = 3.30.013
BQCA + clozapine
 BQCA effectF(4, 165) = 2.70.032
 Clozapine effect F(1, 165) = 31.6<0.001
BQCA + aripiprazole
 BQCA effectF(4, 160) = 2.70.031
 Aripiprazole effectF(1, 160) = 24.6<0.001
 Prepulses × BQCA × Aripiprazole × MK-801 interactionF(4, 320) = 4.50.002
Y-mazeC57Bl/6J10–13BQCA (s.c.) + antipsychotics (i.p.)BQCA alone
 Arm effectF(1, 59) = 17.2<0.001
 Arm × MK-801 effectF(1, 59) = 9.70.003
BQCA + haloperidol
 Arm effect F(1, 124) = 8.40.005
 Arm × MK-801 effectF(1, 124) = 6.40.012
BQCA + clozapine
 Arm effect F(1, 123) = 13.4<0.001
 Arm × MK-801 effectF(1, 123) = 5.10.026
 Arm × BQCA effectF(2, 123) = 3.50.034
BQCA + aripiprazole
 Arm effect F(1, 132) = 18.0<0.001
 Arm × MK-801 effect F(1, 132) = 8.60.004
PPIM1+/+ mice (C57Bl/6 Ntac background)Vehicle and MK-801 controls, 15–16; others, 8–9BQCA (i.p.) + clozapine (i.p.)M1+/+ mice
M1−/− mice (C57Bl/6 Ntac background)Vehicle and MK-801 controls, 13–15; others, 8 MK-801 effect F(1, 67) = 29.0<0.001
 BQCA effectF(2, 67) = 3.20.046
 Clozapine effect F(1, 67) = 8.30.005
M1−/− mice
 MK-801 effect F(1, 61) = 26.2<0.001