Pairwise Comparison | Number of Attributes, by P Value | Top Eight Attributes Ranked by P Valuea | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|

<0.005 | <0.01 | <0.05 | |||||||||

OAT1 versus OCT1 | 27 | 29 | 37 | nof_posCharge (P = 5.95E-23) | nof_negCharge (P = 4.92E-13) | nof_adb (P = 2.4E-12) | nof_ao (P = 3.17E-09) | nof_hbam (P = 2.28E-08) | SP3 Character (P = 1.34E-07) | Number of hydrogens (P = 7.93E-07) | nof_asv (P = 1.11E-06) |

OAT3 versus OCT1 | 17 | 18 | 23 | nof_negCharge (P = 1.10E-16) | nof_posCharge (P = 2.44E-15) | nof_adb (P = 4.98E-13) | nof_ao (P = 3.07E-10) | nof_hbam (P = 7.08E-09) | molPSA (P = 1.38E-06) | SP3 Character (P = 2.7E-06) | Topological polar surface area (P = 3.63E-06) |

OAT1 versus OCT2 | 16 | 21 | 28 | nof_posCharge (P = 1.45E-19) | nof_negCharge (P = 1.31E-13) | nof_adb (P = 1.52E-11) | nof_ao (P = 1.15E-10) | nof_hbam (P = 1.08E-09) | SP3 Character (P = 4.59E-07) | molPSA (P = 8.03E-07) | nof_adv (P = 1.64E-06) |

OAT3 versus OCT2 | 17 | 20 | 27 | nof_negCharge (P = 3.52E-17) | nof_posCharge (P = 8.12E-14) | nof_ao (P = 1.71E-11) | nof_adb (P = 3.24E-11) | nof_hbam (P = 1.27E-09) | Hydrogen Bond Acceptors (P = 1.03E-06) | molPSA (P = 1.32983E-06) | nof_adv (P = 1.66E-06) |

OAT1 versus OAT3 | 1 | 2 | 18 | nof_aqv (P = 0.00257) | nof_posCharge (P = 0.00586) | nof_asv (P = 0.01339) | nof_asb (P = 0.01364) | nof_rbc (P = 0.01432) | molVolume (P = 0.01828) | Fragment Complexity (P = 0.01924) | Number of hydrogens (P = 0.01964) |

OCT1 Versus OCT2 | 6 | 12 | 30 | nof_s (P = 0.00171) | molWeight (P = 0.00382) | LabuteASA (P = 0.00451) | Number of heavy atoms (P = 0.00495) | SMR (P = 0.00497) | nof_hac (P = 0.00514) | Vertex adjacency information magnitude (P = 0.00527) | nof_rings6 (P = 0.00545) |

↵

The Student’s^{a}*t*tests calculated the*P*values for each attribute for each pairwise transporter comparison, and the level of significance is indicated. The results are found to be consistent with the results from the machine-learning analyses.