Plasma and urine concentrations of MK-7145 after oral administration to mongrel dogs
| Collection Time | Plasma Concentration (μM) | Urine Concentration (μM) | ||
|---|---|---|---|---|
| Day 1 | Day 7 | Day 1 | Day 7 | |
| min | ||||
| Control | 0 | 0 | 0 | 0.07 ± 0.02 |
| 0-30 | 0.020 ± 0.025 | 0.005 ± 0.002 | 1.85 ± 1.38 | 1.20 ± 0.39 |
| 30-60 | 0.026 ± 0.020 | 0.025 ± 0.004 | 2.91 ± 1.69 | 1.66 ± 0.62 |
| 60-90 | 0.031 ± 0.017 | 0.039 ± 0.003 | 1.89 ± 1.04 | 0.94 ± 0.19 |
| 90-120 | 0.055 ± 0.027 | 0.050 ± 0.006 | 1.60 ± 0.58 | 1.40 ± 0.24 |
| 120-150 | 0.065 ± 0.028 | 0.059 ± 0.012 | 1.49 ± 0.34 | 1.30 ± 0.38 |
| 150-180 | 0.058 ± 0.013 | 0.060 ± 0.009 | 1.72 ± 0.64 | 1.81 ± 0.40 |
Female mongrel dogs were orally dosed with 0.3 mg/kg MK-7145 in Imwitor742: Tween80 (1:1, v:v), daily for seven days. Plasma and urine samples were collected before and after oral administration of MK-7145 at 30-min interval periods for up to 3 hours postdosing on days 1 and 7. Results are presented as mean ± S.D. (n = 3). Concentrations of MK-7145 were determined by LC-MS/MS.