TABLE 1

Binding potency of ketamine’s enantiomers and metabolites at dopamine receptors

Percent values are the mean of two to five experiments, with four replicates each, and were derived from a single concentration (10 μM). Negative values are represented as 0%.

% Inhibition
(S)-KET(R)-KET(S)-norKET(R)-norKET(S)-DHNK(R)-DHNK(2S,6S)-HNK(2R,6R)-HNK(2R,6S)-HNK(2S,6R)-HNK
Target
D1R124070090260
D2R112025170090
D3R10802030000
D4R4000800060
D5R0000000042
  • D1R, dopamine receptor D1; D2R, dopamine receptor D2; D3R, dopamine receptor D3; D4R, dopamine receptor D4; D5R, dopamine receptor D5; KET, ketamine; norKET, norketamine.