TABLE 1

No pharmacokinetic interactions exist between acute vortioxetine and scopolamine

Bioanalysis of plasma and brain exposure to vortioxetine and scopolamine using administration routes and times relevant for the behavioral experiments presented in this study reveals no pharmacokinetic interactions between vortioxetine and scopolamine. Data are presented as mean ± S.E. N = 8 rats per group.

Treatment GroupVortioxetineScopolamine
Plasma (µM)Brain (µmol/kg)Brain:PlasmaPlasma (nM)Brain (nmol/kg)Brain:Plasma
Scopolamine (0.1 mg/kg, s.c., 30 minutes)00060 ± 6.2330 ± 605.7 ± 1.1
Vortioxetine (10 mg/kg, s.c., 1 hour)2.3 ± 0.1a34 ± 2.615 ± 1.1000
Vortioxetine (10 mg/kg, s.c., 1 hour) + scopolamine (0.1 mg/kg, s.c., 30 minutes)1.9 ± 0.0834 ± 2.917 ± 1.474 ± 7.1340 ± 604.6 ± 0.6
  • a Significant difference from vortioxetine + scopolamine group.