TABLE 1

Comparison of single versus cumulative injections of 6β-naltrexol at 4-hour survival time point

One versus four injections of 10 mg/kg 6β-naltrexol with 4-hour survival time. Values are expressed as the mean ± S.E.M.

1 Injection4 Injections in 24 h
Plasma40 ± 40 (n = 4)60 ± 20 (n = 2)
Adult brain110 ± 40 (n = 4)160 ± 20 (n = 2)
Embryo brain210 ± 60 (n = 2)290 ± 40 (n = 2)
Adult liver280 ± 160 (n = 4)360 ± 50 (n = 2)
Embryo liver250 ± 50 (n = 2)500 ± 190 (n = 2)