Comparison of pharmacokinetic parameters of CP I and CP III following oral administration of vehicle and 15 mg/kg RIF in cynomolgus monkeys
| Parameter | CP I | CP III | ||
|---|---|---|---|---|
| Vehicle | RIF | Vehicle | RIF | |
| AUC(0–48 h) (nM·h) | 14.2 ± 2.2 | 37.6 ± 8.9* | 5.8 ± 0.48 | 20.6 ± 3.1** |
| Xe (0–48 h) (nmol) | 1.5 ± 0.42 | 6.2 ± 2.2* | 21.5 ± 6.1 | 61.8 ± 15.0* |
| CLR (ml/min) | 1.8 ± 0.79 | 2.8 ± 0.92 | 62.9 ± 21.8 | 49.4 ± 5.1 |
| ERR | 0.68 ± 0.34 | 1.1 ± 0.40 | 24.1 ± 9.8 | 18.7 ± 1.7 |
Data are expressed as mean ± S.D. (n = 3); *P < 0.05 and **P < 0.01, statistically significant difference compared to the vehicle control group.