Summary of results of behavioral experiments with JNJ-55511118
| Experiment | Result | Notes |
|---|---|---|
| Anticonvulsant | ||
| PTZ | − | Increased threshold to seizure |
| Corneal kindling | −− | Complete seizure protection |
| Amygdala kindling | −− | Complete seizure protection |
| 6 Hz 32 mA | − | Incomplete protection |
| 6 Hz 44 mA | − | Incomplete protection |
| MES | 0 | |
| General behavior | ||
| Rotarod | 0 | |
| Basal motor activity | + | Transient hyperlocomotion |
| Sleep/wake cycle | − | Decreased sleep duration |
| Sedation | 0 | |
| Learning/memory | ||
| Water maze | − | Minor decrease in learning rate |
| V-maze | − | Minor decrease in performance |
| DNMTP | − | Minor decrease in performance |
| EEG oscillations | ||
| Wake | − | Decrease in theta, alpha, beta |
| NREM | − | Decrease in delta, theta, sigma, beta |
| REM | − | Decrease in delta, theta, beta |
0, no effect; + increased response; –, decreased response; —, strong decreased response.