Inhibitory effects of UR-1102 and benzbromarone on URAT1, OAT1, and OAT3. Figures in parentheses represent the level of URAT1 selectivity on the basis of the Ki value.
| UR-1102 | Benzbromarone | |
|---|---|---|
| URAT1, Ki value | 0.057 ± 0.036 μM | 0.052 ± 0.017 μM |
| OAT1, Ki value (versus URAT1) | 7.2 ± 0.8 μM (130-fold) | 0.22 ± 0.03 μM (4.2-fold) |
| OAT3, Ki value (versus URAT1) | 2.4 ± 0.2 μM (42-fold) | 0.11 ± 0.05 μM (2.1-fold) |
Data represents mean ± S.D. (n = 3).