Compound | Dose (mg/kg/day) | Mean Concentration | |||
---|---|---|---|---|---|
Plasma | Kidney | ||||
Week 5 | Week 10 | Week 15 | Week 15 | ||
BI 703704 | 0.3 | 101 ± 9 | 78 ± 4 | 94 ± 19 | 25 ± 2 |
1 | 524 ± 100 | 319 ± 22 | 496 ± 114 | 83 ± 5 | |
3 | 1129 ± 80 | 1082 ± 79 | 1358 ± 247 | 243 ± 15 | |
10 | 3455 ± 455 | 2815 ± 165 | 3175 ± 130 | 1509 ± 114 | |
Enalaprilat | 3 | 120 ± 21 | 141 ± 21 | 212 ± 23 | 124 ± 13 |
Plasma levels reported as mean ± S.E.M. in nM for BI 703704 and enalaprilat, the active metabolite of enalapril, at weeks 5, 10, and 15 of the study. Kidney concentrations reported in nM for BI 703704 and enalaprilat at week 15.