TABLE 2

Hemodynamic measurements in the eight pressure-regulated experimental groups

Data are presented as means ± S.E.M.

ParameternBaseline (25 min)KV7
Modulation (20 min)ReperfusionTwo-Way ANOVA
+2 min+30 min+120 min
LVDP (mm Hg)
 DMSO6158 ± 8157 ± 94 ± 220 ± 524 ± 5
 IPC7155 ± 6151 ± 96 ± 158 ± 740 ± 40.004
 XE9917150 ± 3149 ± 53 ± 139 ± 749 ± 60.025
 XE991 plus IPC8156 ± 9157 ± 88 ± 290 ± 375 ± 4<0.001
 Linopirdine8144 ± 4163 ± 32 ± 137 ± 544 ± 30.135
 Linopirdine plus IPC8145 ± 11156 ± 134 ± 169 ± 757 ± 6<0.001
 Flupirtine7151 ± 12166 ± 134 ± 224 ± 519 ± 5>0.99
 Flupirtine plus IPC4141 ± 5143 ± 42 ± 033 ± 1117 ± 3>0.99
LVEDP (mm Hg)
 DMSO65 ± 25 ± 291 ± 650 ± 638 ± 7
 IPC76 ± 16 ± 181 ± 1028 ± 528 ± 50.513
 XE99172 ± 33 ± 177 ± 631 ± 317 ± 20.179
 XE991 plus IPC87 ± 16 ± 248 ± 69 ± 415 ± 6<0.001
 Linopirdine81 ± 10 ± 178 ± 328 ± 316 ± 30.064
 Linopirdine plus IPC84 ± 25 ± 268 ± 1019 ± 717 ± 60.010
 Flupirtine78 ± 19 ± 184 ± 854 ± 640 ± 8>0.99
 Flupirtine plus IPC40 ± 10 ± 173 ± 429 ± 6*23 ± 2
Heart rate (beats/min)
 DMSO6268 ± 13282 ± 14253 ± 29290 ± 23248 ± 100,435
 IPC7250 ± 15259 ± 16230 ± 18265 ± 6243 ± 15>0.99
 XE9917258 ± 17240 ± 16199 ± 24240 ± 10218 ± 90.399
 XE991 plus IPC8251 ± 11207 ± 9*204 ± 19242 ± 10215 ± 170.237
 Linopirdine8294 ± 16269 ± 11223 ± 15310 ± 14234 ± 7>0.99
 Linopirdine plus IPC8282 ± 8261 ± 11216 ± 18259 ± 13253 ± 8>0.99
 Flupirtine7275 ± 12256 ± 11198 ± 33217 ± 9*205 ± 180.732
 Flupirtine plus IPC4262 ± 13276 ± 14189 ± 37243 ± 8219 ± 150.536
CF (ml/min)
 DMSO615.9 ± 0.616.0 ± 0.412.4 ± 0.713.5 ± 0.78.3 ± 0.7
 IPC715.4 ± 0.515.5 ± 0.713.0 ± 0.614.3 ± 1.19.9 ± 1.0>0.99
 XE991715.1 ± 0.712.4 ± 0.8*12.1 ± 0.812.5 ± 0.97.6 ± 0.5>0.99
 XE991 plus IPC812.5 ± 0.6*9.2 ± 0.612.4 ± 0.511.7 ± 0.76.9 ± 0.40.944
 Linopirdine816.0 ± 0.716.0 ± 0.812.6 ± 0.714.7 ± 0.710.2 ± 0.6>0.99
 Linopirdine plus IPC814.0 ± 0.713.9 ± 1.112.7 ± 0.913.0 ± 0.99.4 ± 0.8>0.99
 Flupirtine715.0 ± 0.915.0 ± 0.711.2 ± 0.511.9 ± 0.67.7 ± 0.8>0.99
 Flupirtine plus IPC414.0 ± 1.812.4 ± 4.211.7 ± 1.812.2 ± 1.66.6 ± 0.8>0.99
  • CF, coronary flow rate; LVDP, left ventricular developed pressure; LVEDP, left ventricular end diastolic pressure.

  • * P < 0.05 versus DMSO; P < 0.01 versus DMSO; P < 0.001 versus DMSO.