TABLE 2

Summary of findings on modulation of GABAA α1 and α4 subunits by ethanol and kinases

Data are presented as means ± S.E.M. Downward arrows indicate negative modulation, whereas upward arrows indicate positive modulation. The dash indicates no change.

SubunitChronic EthanolPKCPKA
GABAA α1↓ (Kumar et al., 2003)↓ (Kumar et al., 2010)↑ (Carlson et al., 2013)
Extrasynaptic GABAA α4↓ (Liang et al., 2006)a— (Carlson et al., 2016)↑ (Carlson et al., 2016)
Synaptic GABAA α4↑ (Liang et al., 2006)a↑ (This study)↓ (This study)
  • a Note that these studies are in the hippocampus.