TABLE 2

PK parameters after single doses of LY2456302

aGeometric Mean (Geometric %COV)
0.5 mg (n = 2)2 mg (n = 4)4 mg (n = 2)10 mg (n = 4)25 mg (n = 1)
Cmax (ng/ml)0.53–0.904.20 (71%)4.21–5.6312.6 (61%)15.2
btmax (h)1.00–2.552.50 (1.00–4.00)1.00–4.002.50 (2.50–4.00)4.07
AUC (0–tlast) (ng ∣ h / ml)2.42–3.6628.4 (45%)39.5–62.1112 (45%)154
  • a The range for all parameters is reported where n = 2. Individual parameter is reported where n = 1.

  • b Median (range).