TABLE 4

Receptor occupancy and nondisplaceable distribution volume (VND) estimates

LY2456302 Dose2.5 h Postdose24 h Postdose
OccupancyVNDOccupancyVND
%ml/cm3%ml/cm3
0.5 mg (n = 2)35 ± 41.23 ± 0.0619 ± 31.92 ± 0.21
2 mg (n = 4)71 ± 101.32 ± 0.1943 ± 141.41 ± 0.25
4 mg (n = 2)79 ± 61.43 ± 0.1048 ± 11.37 ± 0.03
10 mg (n = 3)94 ± 0.51.43 ± 0.1072 ± 41.51 ± 0.10
25 mg (n = 1)931.50821.40
  • Data are mean ± S.D. Individual parameters are reported where n = 1.