TABLE 3

In vivo cystometry in awake rats: effect of intravesical vehicle or DFL23448 on intravesical PGE₂-induced bladder overactivity

Values are given as means ± S.E.M.

Treatment (Intravesical)	Intervals and Volumes				Pressures
Treatment (Intravesical)	Micturition Interval	Micturition Volume	Residual Volume	Bladder  Capacity	Basal Pressure	Threshold Pressure	Maximum Pressure
	min	ml			cmH₂O
Vehicle (n = 8)
Baseline	4.28 ± 0.80	0.67 ± 0.10	0.02 ± 0.02	0.69 ± 0.10	8.3 ± 1.6	15.7 ± 1.6	78.8 ± 8.3
Vehicle	4.32 ± 0.81	0.68 ± 0.12	0.02 ± 0.01	0.69 ± 0.10	8,0 ± 1.7	15.4 ± 1.9	76.4 ± 7.9
PGE₂	2.69 ± 0.60***	0.41 ± 0.08***	0.04 ± 0.02	0.45 ± 0.10***	10.9 ± 1.9*	18.1 ± 1.7*	104.8 ± 12.8**
DFL23448 (n = 6)
Baseline	3.66 ± 1.02	0.69 ± 0.18	0.001 ± 0.01	0.69 ± 0.18	9.5 ± 0.7	12.8 ± 1.0	40.7 ± 1.9*
10 mg/l DFL23448	5.04 ± 0.98^{^a}	0.85 ± 0.18^{^a}	0.02 ± 0.02	0.87 ± 0.18^{^a}	7.4 ± 0.6	10.7 ± 0.5	55.3 ± 5.8
PGE₂	4.32 ± 0.99	0.75 ± 0.17^{^b}	0.02 ± 0.02	0.77 ± 0.17^{^b}	8.4 ± 0.8	12.4 ± 0.9	56.1 ± 5.9

↵^a Difference versus baseline only.
↵^b P = 0.07 versus vehicle (unpaired t test).
* P < 0.05; **P < 0.01; ***P < 0.001 (Newman-Keuls analysis of variance for repeated measures within groups).