TABLE 2

Five principles of AOP developmenta

Principle NumberPrinciple
1AOPs are not chemical specific.
2AOPs are modular (consisting of KEs and KERs).
3An individual AOP is a pragmatic unit of development and evaluation.
4For most real-world applications, AOP networks are the functional unit of prediction.
5AOPs are living documents.
  • a Villeneuve et al. (2014a).