TABLE 3

Extent of CD28 RO versus inhibition of T-cell-dependent antibody response

MouseMonkey
DoseaROaverageTDAR InhibitionDosebROaverageTDAR Inhibitionc
mg/kg%%mg/kg%%
0.0042100.05260
0.0269780.56279
0.110010058697
  • a Repeat intraperitoneal administration (3 times a week for 2 weeks).

  • b Single subcutaneous dose.

  • c Estimated as the area under the average IgG response-time curve up to day 29.