Effect of chronic in-diet dosing with MLi-2 (30 mg/kg per day) on dopamine, DOPAC, HVA, and TH levels in striatum of MitoPark mice
| Week | Genotype | Dose | DA | DOPAC | HVA | Metabolite/DA Ratio | TH |
|---|---|---|---|---|---|---|---|
| mg/kg per day | ng/g | ng/g | ng/g | % control | |||
| 8 | Wild-type | 0 | 1715 ± 50.71 | 14502 ± 652.1 | 270.0± 6.4 | 9.083 ± 0.8 | 100.0 ± 24.7 |
| MitoPark | 0 | 1110 ± 53.4*** | 9625 ± 332.8*** | 263.5 ± 8.5 | 9.044 ± 0.4 | 54.56 ± 10.2 | |
| MitoPark | 30 | 1114 ± 124.6*** | 8966 ± 375.4*** | 267.6 ± 8.3 | 8.332 ± 0.2 | 49.89 ± 10.4 | |
| 14 | Wild-type | 0 | 2175 ± 232.6 | 20076 ± 1371 | 391.8 ± 53.3 | 9.864 ± 0.6 | 100.0 ± 19.8 |
| MitoPark | 0 | 1037 ± 93.1*** | 6193 ± 533.3*** | 310.1 ± 21.5 | 6.306 ± 0.2*** | 36.70 ± 4.7*** | |
| MitoPark | 30 | 1105 ± 176.2*** | 7521 ± 2145*** | 323.7 ± 36.7 | 6.556 ± 0.5*** | 42.60 ± 7.1*** |
Data are expressed as the mean and ± S.E.M. ***P < 0.001 compared with the vehicle-treated wild-type group.