Effect of autophagy deficiency with or without IM treatment on IEC6 cells or mouse intestinal epithelial cells
| Mice | Epithelial Cell Damage | Autophagy | Apoptosis | Oxidative Stress | ERK/Nrf2/HO-1 |
|---|---|---|---|---|---|
| WT | — | + | + | + | + |
| WT + IM | +++ | +++ | +++ | +++ | ++ |
| Atg5 KO | — | — | + | ++ | ++ |
| Atg5 KO + IM | + | — | ++ | +++ | +++ |
— : not detectable; + : low; ++ : medium; +++ : high.