TABLE 2

Summary of steady-state concentrations

DTI = (Brain-to-plasma ratio)knockout/(Brain-to-plasma ratio)wild type.

StrainCss PlasmaCss BrainBrain-to-Plasma RatioDTI
nMnM
Wild type53.8 ± 633.82 ± 1.10.2 ± 0.071.0
Bcrp1−/−103 ± 5732.3 ± 110.4 ± 0.12.0
Mdr1a/b−/−139 ± 35315 ± 862.5 ± 0.112.5
Mdr1a/b−/−Bcrp1−/−92.3 ± 492510 ± 140028 ± 6140
  • DTI, drug targeting index.