TABLE 3

Pharmacokinetic variables of a single dose of 10 mg rosuvastatin in 62 healthy Chinese subjects with ABCG2 c.34G>A and c.421C>A variants

VariableHaplotype
34GG/421CC (n = 10)34GA/421CC (n = 9)34AA/421CC (n = 9)34GG/421AA (n = 10)34GG/421CA (n = 8)34GA/421CA (n = 16)
Cmax (ng/ml)8.1 ± 1.88.1 ± 1.316.9 ± 6.0a,b26.5 ± 12.5c8.8 ± 4.214.1 ± 5.2a,b
AUC(0–48 h) (ng·h/ml)95.5 ± 26.281.6 ± 15.9153.6 ± 57.1a,b252.2 ± 66.0c98.8 ± 42.8159.8 ± 57.4a,b
AUC(0–∞) (ng·h/ml)97.7 ± 26.984.2 ± 18.5157.9 ± 58.4a,b258.4 ± 66.7c101.4 ± 42.9165.0 ± 58.7a,b
CL/F (l/h)111.1 ± 39.1125.4 ± 30.974.1 ± 34.4a41.4 ± 12.4c114.7 ± 47.866.9 ± 20.0a,b
t1/2 (h)12.7 ± 2.114.3 ± 3.013.6 ± 2.413.2 ± 3.114.3 ± 1.914.4 ± 2.5
Tmax (h)3.8 ± 2.43.4 ± 1.32.4 ± 1.03.6 ± 1.63.5 ± 1.83.4 ± 1.4
  • a P < 0.01.

  • b P < 0.05 compared with the 34GG/421AA group (Student-Newman-Keuls test).

  • c P < 0.001 compared with the 34GG/421CC, 34GA/421CC, and 34GG/421CA group.