Urinary excretion of RSV after a single oral dose of 3 mg/kg RSV with and without 100 mg/kg oral CsA in cynomolgus monkeys
Data reported as mean ± S.D., n = 3 different animals.
| Parameter | Animal 1 | Animal 2 | Animal 3 | Average | ||||
|---|---|---|---|---|---|---|---|---|
| RSV Alone | CsA + RSV | RSV Alone | CsA + RSV | RSV Alone | CsA + RSV | RSV Alone | CsA + RSV | |
| Body weight (kg) | 3.4 | 3.4 | 3.9 | 3.7 | 4.1 | 4.2 | 3.8 ± 0.4 | 3.8 ± 0.4 |
| Xe, 0–48 h (nmol) | 120.6 | 925.1 | 253.9 | 1819.0 | 267.9 | 960.2a | 214.1 ± 81.3 | 1234.8 ± 506.3 |
| Xe, 0–48 h (% dose) | 0.6 | 4.5 | 1.1 | 8.1 | 1.1 | 3.8a | 0.92 ± 0.29 | 5.5 ± 2.3 |
| AUC0–inf (nM⋅h) | 95.8 | 706.3 | 162.9 | 1424.4 | 143.0 | 561.8 | 133.9 ± 34.5 | 897.5 ± 462.0 |
| CLR (ml/min/kg) | 6.1 | 6.3 | 6.7 | 5.7 | 7.6 | 6.8a | 6.8 ± 0.7 | 6.3 ± 0.6 |
CLR renal clearance; Xe, 0–48 h, amount or percentage of RSV recovered in urine over 48 hours.
↵a The urine sample collected between 0 and 7 hours from animal 3 was contaminated, the amount of RSV excreted into urine during the interval was not included into the cumulative excretion.