TABLE 1

[3H]DA uptake inhibition by select SRI compounds: one-component versus two-component fits

Dose-response curves (eight points) reported in Fig. 2 were fit to one- and two-component equations for the best-fit estimates of the IC50 and Emax values (± S.D.).

DrugOne-Site IC50One-Site EmaxTwo-Site IC50-1Two-Site Emax1Two-Site IC50-2Two-Site Emax2Sum-of-Squares One-Site FitSum-of-Squares Two-Site FitF Test
nM%InM%InM%I
SRI-2998618 ± 475 ± 318 × 105 ± 1.7 × 10537 × 108 ± 2.7 × 10818 × 105 ± 1 × 10537 × 108 ± 0.7 × 1081751750
SRI-31335156 ± 12100 ± 1.599 ± 6376 ± 54564 ± 117727 ± 5328.919.01.56
SRI-3083515 ± 775 ± 56 ± 0.957 ± 24000 ± 133042 ± 467714.2140*
  • * P < 0.001 vs. one-component fit (F test).