Genes differentially expressed after 4,4′-DiOMEA treatment
Microarray data of differentially expressed genes after treatment of human colon cancer SW-620 cells with 5 μM 4,4′-DiOMEA for 72 hours (conditions in which antiproliferative activity is observed). The experiment was repeated four times, each performed in triplicate per test concentration. Genes showing a statistical significant differential expression (P < 0.05) and more than 2-fold absolute change variation are shown. Presented data include fold changes, intensity values (control, logControl; treated, logExperiment), S.E.M. values, and P values for the Limma package (linear models for microarray data).
| Gene | Accession Number | Fold Change | logControl | S.E.M. (logControl) | logExperiment | S.E.M. (logExperiment) | P Value (Limma) | Description |
|---|---|---|---|---|---|---|---|---|
| RHBDL1 | NM_001278720 | −2.54 | 13.67 | 0.1 | 12.33 | 0.7 | 0.039 | Homo sapiens rhomboid, veinlet-like 1 (Drosophila) (RHBDL1), transcript variant 1 |
| A4GALT | NM_017436 | −2.49 | 14.02 | 0.3 | 12.71 | 0.5 | 0.016 | H. sapiens α1,4-galactosyltransferase (A4GALT) |
| WNT16 | NM_057168 | −2.3 | 7.14 | 0.7 | 5.94 | 0.1 | 0.05 | H. sapiens wingless-type MMTV integration site family, member 16 (WNT16), transcript variant 1 |
| PCSK1N | NM_013271 | −2.19 | 14.66 | 0.3 | 13.53 | 0.5 | 0.029 | H. sapiens proprotein convertase subtilisin/kexin type 1 inhibitor (PCSK1N) |
| PAPPA | NM_002581 | −2.12 | 7.36 | 0.6 | 6.27 | 0.1 | 0.033 | H. sapiens pregnancy-associated plasma protein A, pappalysin 1 (PAPPA) |
| WDR52 | NM_001164496 | 4.5 | 6.4 | 0.1 | 8.57 | 1.2 | 0.039 | H. sapiens WD repeat domain 52 (WDR52), transcript variant 1 |
| MUSK | NM_005592 | 2.46 | 6.47 | 0.1 | 7.77 | 0.7 | 0.044 | H. sapiens muscle, skeletal, receptor tyrosine kinase (MUSK), transcript variant 1 |
| GRHL1 | NM_198182 | 2.2 | 6.5 | 0.1 | 7.64 | 0.5 | 0.013 | H. sapiens grainyhead-like 1 (Drosophila) (GRHL1) |
| GTF2I | ENST00000473333 | 2.1 | 6.17 | 0 | 7.24 | 0.3 | 0.002 | General transcription factor Iii |
| SLC22A8 | ENST00000451262 | 2.06 | 7.13 | 0.1 | 8.18 | 0.3 | 0.002 | Solute carrier family 22 (organic anion transporter), member 8 |
| S100A5 | NM_002962 | 2.05 | 7.95 | 0.2 | 8.98 | 0.4 | 0.013 | H. sapiens S100 calcium binding protein A5 (S100A5) |