TABLE 2

In vitro evaluation of CsA as an inhibitor of RSV uptake into hepatocytes and HEK-293 cells expressing individual transporter

Data are represented as mean ± S.D. (n = 3 determinations) (see Materials and Methods).

CellsIC50a
HepatocytesOATP1B1OATP1B3NTCP
µM
Human0.30 ± 0.080.21 ± 0.100.13 ± 0.062.1 ± 0.9b
Cynomolgus monkey0.29 ± 0.110.28 ± 0.110.25 ± 0.093.9 ± 2.0

  • ↵a IC50 values were generated at a low concentration of RSV (0.1 µM).

  • ↵b IC50 was average of the values generated from 55 different test occasions using [3H]TCA (1 μM) as probe substrate.