PK parameters of CNP variants in wild-type rats [Crj:CD (SD) IGS] and wild-type mice [FVB/nJ]
Data are expressed with the S.D. in parentheses if applicable.
| Group | Animal | Dose | Route | Cmax | tmax | t1/2 | Bioavailability |
|---|---|---|---|---|---|---|---|
| nmol/kg | pmol/ml | min | min | % | |||
| CNP22 | Rat | 20 | i.v. | NA | NA | 1.4 (0.5) | NA |
| PEO24-CNP27 | Rat | 20 | i.v. | NA | NA | 22 (1.5) | NA |
| PEO12-CNP27 | Rat | 20 | i.v. | NA | NA | 17 (1.3) | NA |
| BMN 1B2 | Rat | 20 | i.v. | NA | NA | 23 (3.4) | NA |
| HSA(27–36)-CNP27 | Rat | 20 | i.v. | NA | NA | 23 (1.1) | NA |
| CNP22 | Mice | 50 | i.v. | 7.3 (1.1) | 1 (0) | ≤2 | NA |
| BMN 111 | Mice | 25 | i.v. | 250 (86) | 1.5 (1) | 14 | NA |
| CNP22 | Rat | 50 | s.c. | 9.0 (3.7) | 5.0 (0.0) | 10 (5.0) | 19 (9.0) |
| PEO24-CNP27 | Rat | 50 | s.c. | 24 (1.9) | 25 (8.7) | 78 (16) | 60 (6.0) |
| PEO12-CNP27 | Rat | 50 | s.c. | 15 (1.8) | 12 (5.8) | 25 (4.4) | 24 (1.0) |
| BMN 1B2 | Rat | 50 | s.c. | 9.4 (2.2) | 12 (5.8) | 19 (4.3) | 19 (4.0) |
| HSA(27–36)-CNP27 | Rat | 50 | s.c. | 22 (4.4) | 5.0 (0.0) | 25 (8.5) | 25 (3.0) |
| CNP22 | Mice | 130 | s.c. | 10 (3.2) | 2.8 (1.5) | ≤5 | 100 |
| BMN 111 | Mice | 70 | s.c. | 200 (140) | 13 (5) | 15 | 98 |
NA, not available.