TABLE 1

In vivo seizure control data for active compounds

Summary of in vivo seizure control in multiple models.

Compound	Species	Seizure Model	Dose	Animals		ED₅₀
Compound	Species	Seizure Model	Dose	Protected/Tested	Toxic/Tested	ED₅₀
			mg/kg			mg/kg
4-MOA^{^a}	Mice	6 Hz	100	0/4	0/4	ND
5-MOA^{^a}	Mice	6 Hz	300	1/4	0/4	ND
	Rat	MES	300	2/4	0/4	ND
4-MNA^{^a}	Mice	6 Hz	100	0/4	0/4	ND
4-EOA^{^a}	Mice	6 Hz	150	7/8	ND	110
	Rat	MES	125	12/16	4/15^{^b}	100
	Mice	scMET	200	8/8	4/8^{^c}	142
	Mice	CKM	110	6/8	0/8	71
4-BCCA^{^a}	Mice	6 Hz	100	3/4	0/4	81
	Rat	MES	100	4/8	1/8^{^b}	∼100^{^d}
	Mice	scMET	150	4/8	0/8	∼150^{^d}
	Mice	CKM	80	8/8	0/8	44
VPA	Mice	6 Hz	ND	ND	ND	263^{^e}
	Rat	MES	ND	ND	ND	485^{^f}
	Mice	scMET	ND	ND	ND	191^{^g}
	Mice	CKM	ND	ND	ND	174^{^h}

CKM, corneal kindled mouse model; ND, not determined.
↵^a Data provided by collaborative research with the National Institutes of Health National Institute of Neurological Disorders and Stroke.
↵^b Unable to grasp rotorod.
↵^c Ataxia/loss of righting reflex.
↵^d Based on single dose data.
↵^e Data previously determined by Barton et al. (2001).
↵^f Data previously determined by Loscher (1999).
↵^g Data previously determined by Rowley and White (2010).
↵^h Data previously determined by the National Institutes of Health National Institute of Neurological Disorders and Stroke.