Compound | Drug Alone | Plus PNU-120596a | ||
---|---|---|---|---|
Imax | EC50 | IC50 | Normalized Response | |
µM | ||||
tetMA | 1.06 ± 0.03 | 30 ± 3 | 96 ± 28 | |
EtriMA | >4 | >300 | 41 ± 8 | |
diEdiMA | 0.9 ± 0.01 | 31 ± 1 | 55 ± 10 | |
triEMA | 0.15 ± .01 | 107 ± 43 | 68 ± 11 | |
TEA | 80 ± 5 | 5.6 ± 2.5 | ||
Choline | 1.1 ± 0.1 | 270 ± 30 | 23 ± 7 | |
(2OHE)-EdiMA | 1.5 ± 0.3 | 1500 ± 300 | 173 ± 50 | |
(2OHE)-diEMA | >10,000 | 24 ± 9 | ||
BtriMA | 0.47 ± 0.02 | 39 ± 5 | 38 ± 20 | |
BEdiMA | 67 ± 2 | 27 ± 8 | ||
BdiEMA | 42 ± 4 | 25 ± 12 | ||
BtriEA | 26 ± 1 | 0.18 ± 0.07 | ||
diMPyrr | 1.0 ± 0.1 | 18 ± 3 | 16 ± 3 | |
EMPyrr | 0.9 ± 0.1 | 50 ± 1 | 46 ± 11 | |
diEPyrr | 0.38 ± 0.03 | 180 ± 33 | 350 ± 100 | 24 ± 6 |
diMPip | 0.8 ± 0.1 | 24 ± 2 | 49 ± 10 | |
EMPip | 350 ± 100 | 31 ± 4 | ||
diEPip | 200 ± 70 | 5.1 ± 1.9 | ||
diMHHA | 0.29 ± 0.01 | 183 ± 7 | 15 ± 3.5 | |
EMHHA | 159 ± 36 | 0.14 ± 0.06 | ||
diEHHA | 40 ± 8 | 0.23 ± 0.15 |
↵a Data for choline and related compounds were obtained at 1 mM plus 10 µM PNU-120596; data for all other compounds were obtained at 100 µM plus 10 µM PNU-120596. Values are for net charge relative to responses evoked by 60 µM ACh applied alone to the same cells.