Pharmacokinetic properties of RO5126946
| Dose (p.o.) | Dose (i.v.) | |||
|---|---|---|---|---|
| 1 mg/kg | 3 mg/kg | 10 mg/kg | 3 mg/kg | |
| Cmax (ng/ml) | 214 ± 81 | 1050 ± 31 | 3470 ± 357 | 3490 ± 1414 |
| Tmax (h) | 2.5 | 4.67 | 3.33 | |
| t1/2 (h) | 5.19 | 4.00 | 2.61 | 4.90 |
| AUC (ng*h/ml) | 2280 | 11,800 | 25,900 | 11,600 |
| n = 2 | n = 3 | n = 3 | n = 3 | |