Maximal % AZD9272 responding ED50 and confidence limits, and maximal effects on response rates, in rats trained to discriminate AZD9272 from no drug
| Compound | Max % Drug Responding | Max Response Rate Effects | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| At Dose | Mean | S.E.M. | ED50 (95% CL) | Rats Responding (Rats Tested) | At Dose | Mean | S.E.M. | % of Veh | Rats Responding (Rats Tested) | |
| mg/kg | mg/kg | |||||||||
| AZD9272 | 0.28 | 87.52 | 12.03 | 0.21 (0.03–1.76) | 8 (8) | 0.28 | 1.89 | 0.24 | 117 | 8 (8) |
| PCP | 0.28 | 17.16 | 16.57 | <50% | 6 (6) | 1.59 | 1.88 | 0.26 | 121 | 6 (6) |
| MTEP | 2.00 | 50.04a | 22.14 | 1.74 (1.13–2.67) | 6 (6) | 2.00 | 1.58 | 0.19 | 86 | 6 (6) |
| Fenobam | 8.00 | 99.96 | 0.04 | 1.50 (0.17–12.81) | 6 (6) | 0.80 | 1.45 | 0.19 | 96 | 6 (6) |
| AZD2066 | 3.82 | 83.37 | 16.59 | 0.46 (0.09–2.35) | 6 (6) | 3.82 | 1.72 | 0.23 | 96 | 6 (6) |
CL, confidence limit; Veh, vehicle.
↵a Note that the 2.0 mg/kg dose was the highest dose tested. See Discussion for further details.