TABLE 1

Maximal % drug responding ED50 and confidence limits, and maximal effects on response rates in rats trained to discriminate cocaine, PCP, chlordiazepoxide, (−)-Δ9-THC, or MTEP from no drug

CompoundMax % Drug RespondingMax Response Rate Effects
At DoseMeanS.E.M.ED50 (95% CL)Rats Responding (Rats Tested)At DoseMeanS.E.M.% of VehRats Responding (Rats Tested)
mg/kgmg/kg
Cocaine10.1999.950.030.46 (0.29–0.73)8 (8)10.192.170.201078 (8)
AZD927228.4217.7318.06<50%6 (6)8.530.800.17436 (6)
PCP1.5999.580.260.6 (0.44–0.82)8 (8)0.502.240.091148 (8)
AZD92728.5316.4116.41<50%6 (6)2.841.440.19706 (6)
Chlordiazepoxide18.83100.00.002.2 (0.94–5.16)8 (8)18.830.960.29748 (8)
AZD92720.8516.7318.16<50%6 (6)28.421.020.11696 (6)
(−)-Δ9-THC2.9999.980.031.01 (0.22–4.53)8 (8)2.992.160.351238 (8)
AZD92728.5337.3920.90<50%6 (6)8.531.210.25716 (6)
MTEP2.0099.010.690.42 (0.34–0.53)8 (8)2.001.580.11978 (8)
AZD92728.5399.980.030.11 (0.02–0.69)8 (8)8.531.630.10968 (8)
  • CL, confidence limit; Veh, vehicle.