TABLE 2 Tyrosine kinase inhibition of nintedanib in a cellular BA/F3 assay
To compare the cellular activity of nintedanib on specific tyrosine kinase receptors, it was tested at 10–1000 nM in BA/F3 cells engineered to be proliferation-dependent on a single tyrosine kinase. IC50 values for nintedanib to inhibit cell proliferation dependent on specific tyrosine kinases are listed in nanomoles.