TABLE 3

MTEP discrimination, maximal % MTEP responding ED50 and confidence levels, and maximal effects on response rates

CompoundMax % MTEP RespondingResponses/sec
At DoseMeanS.E.M.ED50Rats Responding (Rats Tested)At DoseMeanS.E.M.% of VehicleRats Responding (Rats Tested)
mg/kg95% CLmg/kg
MTEP2.0099.010.690.42 (0.34–0.53)8 (8)2.001.580.11978 (8)
MPEP6.8999.970.030.62 (0.44–0.87)7 (7)2.301.410.07917 (7)
Fenobam8.06100.000.000.96 (0.69–1.33)6 (6)2.691.370.12876 (6)
(+)-MK-8010.1967.3022.920.15 (0.12–0.18)4 (6)0.191.050.28744 (6)
Memantine12.9554.2514.3911.42 (5.70–22.86)7 (7)12.950.800.19477 (7)
Phenylcyclidine2.8027.5516.00N/A7 (7)2.801.460.24907 (7)
LSD s.c.0.3047.3019.75N/A5 (7)0.300.550.16335 (7)
LSD i.p.0.3035.4419.58N/A6 (7)0.300.680.16466 (7)
CDP18.8040.0419.29N/A6 (7)18.800.850.21496 (7)
(−)-Δ9-THC0.0916.6716.43N/A6 (6)0.940.670.24384 (6)
Yohimbine1.000.520.17N/A8 (8)3.001.940.17918 (8)
Arecoline5.6019.7419.69N/A5 (7)10.000.000.0000 (7)
Pentylenetetrazol 17.500.060.04N/A6 (6)17.501.310.12716 (6)
  • N/A, not applicable.