TABLE 2

Maximal responses (E_max) and potency (pEC₅₀) values derived from concentration–response curves to BAY 41-2272 (0.0001–30 μM) and BAY 60-2770 (0.0001–30 μM) in urethra smooth muscle from lean and obese mice in the presence and absence of 1H-[1,2,4] oxadiazolo [4,3-a]quinoxalin-1-one (ODQ; 10 μM)

Data are presented as mean ± S.E.M. (n = 4–8). Values of E_max are represented as percentage.

Group	BAY 41-2272		BAY 60-2770
Group	E_max	pEC₅₀	E_max	pEC₅₀
	%		%
Lean	75.9 ± 2.3	6.65 ± 0.05	41.9 ± 2.7	7.19 ± 0.08
Obese	60.9 ± 0.5^{^a}	6.46 ± 0.06	63.4 ± 4.0^{^b}	7.75 ± 0.07^{^a}
Lean + ODQ	54.4 ± 3.9^{^b}	6.91 ± 0.07	59.7 ± 0.4^{^a}	7.33 ± 0.04
Obese + ODQ	42.0 ± 3.5^{^c}	6.49 ± 0.08	72.7 ± 5.9	7.24 ± 0.08

↵^a P < 0.05 compared with respective untreated lean group.
↵^b P < 0.01 compared with respective untreated lean group.
↵^c P < 0.01 compared with obese group (ANOVA followed by a Tukey test).