TABLE 3

Effect of adenosine receptor agonists on CRE-dependent transcription in 6×CRE BEAS-2B luciferase reporter cells

TreatmentNp[A]50Maximum Fold Induction
Bay 60-658317−7.96 ± 0.1115.5 ± 0.8
NECA8−6.74 ± 0.1413.9 ± 0.5
CV 18083>–5.5a10.1 ± 1.0a
CGS 216807>–5.0a8.8 ± 1.4a
  • a Full E/[A] curves could not be determined. Fold enhancement is that produced by 10 and 30 μM CV 1808 and CGS 21680, respectively. Data calculated from Fig. 2A.