TABLE 1

Pharmacokinetic parameters (± S.D.) after i.v. administration of AMG 416

ModelCmaxAUCallClobst1/2
ng/mlh⋅ng/mlml/h/kgh
Normal1662 ± 1873713 ± 346271 ± 251.32 ± 0.19
5/6 Nx1560 ± 1705063 ± 781201 ± 26*2.00 ± 0.57
Double Nx1428 ± 17111,412 ± 1008**81 ± 5b6.68 ± 1.18**
  • AUCall, area under the curve from the time of dosing to the time of last observation; Clobs, observed clearance from plasma.

  • * P < 0.01 vs. normal; **P < 0.001 vs. normal.