TABLE 1

Pharmacokinetic parameters (± S.D.) after i.v. administration of AMG 416

Model	C_max	AUC_all	Cl_obs	t_1/2
	ng/ml	h⋅ng/ml	ml/h/kg	h
Normal	1662 ± 187	3713 ± 346	271 ± 25	1.32 ± 0.19
5/6 Nx	1560 ± 170	5063 ± 781	201 ± 26^*	2.00 ± 0.57
Double Nx	1428 ± 171	11,412 ± 1008**	81 ± 5^b	6.68 ± 1.18**

AUC_all, area under the curve from the time of dosing to the time of last observation; Cl_obs, observed clearance from plasma.
↵* P < 0.01 vs. normal; **P < 0.001 vs. normal.