TABLE 1

Softness, electrophilicity, and IC₅₀ values for quinone and α,β-unsaturated carbonyl derivatives

Softness (σ) and electrophilicity (ω) for the selected compounds were calculated as described under Materials and Methods. The respective IC₅₀ values represent in vitro electrophile concentrations that produce 50% thiol loss and reflect the relative electrophilic potency of each chemical.