Comparison of IC50 values for the inhibition of OCT2-mediated MPP transport in the present study (column A) or in the study of Zolk et al. (2009) (column B)
| Inhibitor | AaIC50 | BbIC50 |
|---|---|---|
| μM | ||
| Imipramine | 3.9 ± 0.9 (6, 3) | 6 |
| Clonidine | 6.0 ± 1.1 (4, 2) | 16 |
| Carvedilol | 55.2 ± 4.2 (3) | 63 |
| Propranolol | 71.6 ± 18.1 (2) | 229 |
| Verapamil | 91.9 ± 35.6 (2, 2) | 85 |
| Chloroquine | 129 ± 22.0 (4) | 1096 |
| Quinidine | 91.6 ± 27.6 (5, 2) | 87 |
| Cimetidine | 171 ± 51.0 (7, 4) | 120 |
| Metformin | 566 ± 107 (3, 5) | 398 |
| Trimethoprim | 775 ± 264 (4) | 1318 |
↵a IC50 values represent the mean (± S.E.) of the number of separate experiments indicated in parentheses. In some cases the values include experiments with OCT2 expressed in both Chinese hamster ovary and HEK293 cells (HEK293 values indicated in italics).
↵b The values were obtained from graphical interpolation of data presented in Fig. 6c from Zolk et al. (2009).