TABLE 3
Summary of rotorod drug toxicity from isobolographic analysis at 20% reduction in motor performance
Clonazepam:Tiagabine (Ratio)
Clonazepam
Tiagabine
Dose mg/kg (95% confidence interval)
Observed: Alone
0.27 (0.10–0.55)
3.8 (3.1–4.4)
1:1
0.23 (0.12–0.35)
0.97 (0.48–1.5)
Predicted
1:1
0.23 (0.17–0.35)
0.97 (0.72–1.5)