Summary of doses for protection against GTC to 41.0°C from isobolographic analysis
| Clonazepam:Tiagabine (Ratio) | Clonazepam | Tiagabine | Interaction index |
|---|---|---|---|
| Dose mg/kg (95% confidence interval) | Observed/Predicted (95% confidence interval) | ||
| Observed: Alone | 0.55 (0.30–1.1) | 2.0 (1.0–6.8) | |
| 2:1 | 0.22 (0.14–0.32) | 0.33 (0.22–0.50) | 0.54 (0.34–0.82) |
| 1:1 | 0.11 (0.091–0.14) | 0.46 (0.38–0.60) | 0.44 (0.25–0.76) |
| 1:4 | 0.063 (0.045–0.084) | 0.85 (0.60–1.1) | 0.57 (0.24–0.96) |
| Predicted | |||
| 2:1 | 0.40 (0.35–0.48) | 0.62 (0.55–0.74) | |
| 1:1 | 0.25 (0.23–0.29) | 1.0 (0.97–1.2) | |
| 1:4 | 0.11 (0.098–0.14) | 1.5 (1.3–1.9) | |