Pharmacokinetic parameters of RSV after oral administration of RSV (3 mg/kg) to cynomolgus monkeys dosed with and without RIF (15 mg/kg by mouth single dose)
Data reported as mean ± S.D., n = 3 different animals.
Analyte | Parameter | Control (RSV Alone) | RIF-Treatmenta | Ratiob | 90% CI |
---|---|---|---|---|---|
RSV | Cmax (nM) | 16.4 ± 11.7 | 113.2 ± 29.0 | 10.23 ± 8.60 (7.15, 3.59, 19.95)d | 1.87-34.26 |
AUC0-last (nM•hr) | 160 ± 99 | 419 ± 108 | 3.04 ± 1.25 | 1.44-5.72 | |
AUC0-inf (nM•hr) | 176 ± 109 | 439 ± 110 | 2.89 ± 1.11 (2.74, 1.86, 4.06)d | 1.42-5.31 | |
tmax (hr) | 5.0 (5.0, 5.0, 5.0)c | 1.0 (1.0, 1.0, 1.0)c | 0.2 ± 0.0 | ||
t1/2 (hr) | 6.1 ± 0.3 | 5.8 ± 1.1 | 0.96 ± 0.22 | 0.64-1.39 | |
RIF | Cmax (µM) | 9.2 ± 2.5 | |||
Clast (µM) | 0.19 ± 0.16 | ||||
AUC0-last (µM•hr) | 67.4 ± 14.9 | ||||
tmax (hr) | 3.3 ± 0.6 | ||||
t1/2 (hr) | 3.7 ± 0.5 |