TABLE 5

Pharmacokinetic parameters of RSV after oral administration of RSV (3 mg/kg) to cynomolgus monkeys dosed with and without RIF (15 mg/kg by mouth single dose)

Data reported as mean ± S.D., n = 3 different animals.

AnalyteParameterControl (RSV Alone)RIF-TreatmentaRatiob90% CI
RSVCmax (nM)16.4 ± 11.7113.2 ± 29.010.23 ± 8.60 (7.15, 3.59, 19.95)d1.87-34.26
AUC0-last (nM•hr)160 ± 99419 ± 1083.04 ± 1.251.44-5.72
AUC0-inf (nM•hr)176 ± 109439 ± 1102.89 ± 1.11 (2.74, 1.86, 4.06)d1.42-5.31
tmax (hr)5.0 (5.0, 5.0, 5.0)c1.0 (1.0, 1.0, 1.0)c0.2 ± 0.0
t1/2 (hr)6.1 ± 0.35.8 ± 1.10.96 ± 0.220.64-1.39
RIFCmax (µM)9.2 ± 2.5
Clast (µM)0.19 ± 0.16
AUC0-last (µM•hr)67.4 ± 14.9
tmax (hr)3.3 ± 0.6
t1/2 (hr)3.7 ± 0.5
  • AUC, area under the concentration-time curve; CI, confidence interval; RIF, rifampin; RSV, rosuvastatin.

  • a RIF was dosed 1 hour prior to RSV.

  • b Represents the parameter ratio (+RIF/−RIF).

  • c Mean (individual value).

  • d Mean ± S.D. (individual value).