TABLE 5

Pharmacokinetic parameters of RSV after oral administration of RSV (3 mg/kg) to cynomolgus monkeys dosed with and without RIF (15 mg/kg by mouth single dose)

Data reported as mean ± S.D., n = 3 different animals.

Analyte	Parameter	Control (RSV Alone)	RIF-Treatment^a	Ratio^b	90% CI
RSV	C_max (nM)	16.4 ± 11.7	113.2 ± 29.0	10.23 ± 8.60 (7.15, 3.59, 19.95)^d	1.87-34.26
	AUC_0-last (nM•hr)	160 ± 99	419 ± 108	3.04 ± 1.25	1.44-5.72
	AUC_0-inf (nM•hr)	176 ± 109	439 ± 110	2.89 ± 1.11 (2.74, 1.86, 4.06)^d	1.42-5.31
	t_max (hr)	5.0 (5.0, 5.0, 5.0)^c	1.0 (1.0, 1.0, 1.0)^c	0.2 ± 0.0
	t_1/2 (hr)	6.1 ± 0.3	5.8 ± 1.1	0.96 ± 0.22	0.64-1.39
RIF	C_max (µM)		9.2 ± 2.5
	C_last (µM)		0.19 ± 0.16
	AUC_0-last (µM•hr)		67.4 ± 14.9
	t_max (hr)		3.3 ± 0.6
	t_1/2 (hr)		3.7 ± 0.5

AUC, area under the concentration-time curve; CI, confidence interval; RIF, rifampin; RSV, rosuvastatin.
↵a RIF was dosed 1 hour prior to RSV.
↵b Represents the parameter ratio (+RIF/−RIF).
↵c Mean (individual value).
↵d Mean ± S.D. (individual value).