IC50 (µM)a | ||||||
---|---|---|---|---|---|---|
Compound | cOATP1B1b | hOATP1B1b | cOATP1B3c | hOATP1B3c | cOATP2B1d | hOATP2B1d |
RIF | 0.20 ± 0.08 | 0.55 ± 0.07 | 1.4 ± 0.5 | 0.46 ± 0.13 | 69.1 ± 7.5 | 40.1 ± 5.1 |
CsA | 1.0 ± 0.3 | 0.87 ± 0.29 | 0.50 ± 0.11 | 0.80 ± 0.22 | >50 | >50 |
Ritonavir | 0.49 ± 0.14 | 1.3 ± 0.3 | 1.3 ± 0.6 | 4.0 ± 1.1 | 4.5 ± 1.8 | 10.7 ± 2.3 |
Gemfibrozil | 20.2 ± 5.8 | 41.4 ± 9.0 | 22.4 ± 6.6 | 50.1 ± 27.3 | >100 | >100 |
Verapamil | 13.5 ± 2.8 | 14.8 ± 3.1 | 52.7 ± 15.9 | 87.3 ± 35.8 | >200 | >200 |
Saquinavir | 2.9 ± 0.9 | 1.6 ± 0.4 | 3.6 ± 1.5 | 5.5 ± 3.0 | 12.3 ± 4.8 | 9.4 ± 3.2 |