RIF as an inhibitor of RSV uptake into hepatocytes and HEK-293 cells expressing individual OATPs
| IC50 (µM)a | ||||
|---|---|---|---|---|
| Hepatocytes | OATP1B1 | OATP1B3 | OATP2B1 | |
| Cynomolgus monkey | 0.28 ± 0.16 | 0.42 ± 0.09 | 1.69 ± 0.28 | 81.6 ± 15.2 |
| Human | 0.90 ± 0.45 | 1.10 ± 0.28 | 0.49 ± 0.13 | 89.8 ± 5.4 |
HEK-293, human embryonic kidney 293 cells; OATP, organic anion–transporting peptide; RIF, rifampin; RSV, rosuvastatin.
↵a IC50 values were generated at a low concentration of RSV (0.1 µM) and data are represented as the mean ± S.D. (n = 3 to 4 determinations) (see Materials and Methods).