TABLE 4

RIF as an inhibitor of RSV uptake into hepatocytes and HEK-293 cells expressing individual OATPs

IC50 (µM)a
HepatocytesOATP1B1OATP1B3OATP2B1
Cynomolgus monkey0.28 ± 0.160.42 ± 0.091.69 ± 0.2881.6 ± 15.2
Human0.90 ± 0.451.10 ± 0.280.49 ± 0.1389.8 ± 5.4
  • HEK-293, human embryonic kidney 293 cells; OATP, organic anion–transporting peptide; RIF, rifampin; RSV, rosuvastatin.

  • a IC50 values were generated at a low concentration of RSV (0.1 µM) and data are represented as the mean ± S.D. (n = 3 to 4 determinations) (see Materials and Methods).