Pharmacokinetic metrics in FVB wild-type and Mdr1a/b−/−Bcrp1−/− mice after oral dosing with 25 mg/kg dabrafenib
Data are presented as the mean ± S.D.
AUC, area under the curve; FVB, Friend leukemia virus strain B; Kp, AUCbrain/AUCplasma.
↵a Area under the curve from time zero to 4 hours postdose.
↵b Kp in Mdr1a/b−/−Bcrp1−/− mice/Kp in wild-type mice.
↵c P = 0.0414 compared with wild-type plasma.
↵d P = 0.002 compared with wild-type brain.