TABLE 6

Observed and predicted RSV AUC ratios with RIF as an inhibitor in cynomolgus monkeys and humans

Species	AUC Ratio (Observed)	90% CI of AUC Ratio	AUC Ratio (Predicted)
			Prediction Method^a	I_max		I_ave		I_in,max
			Prediction Method^a	Total	Free	Total	Free	Total	Free
Cynomolgus Monkey	2.89	1.42–5.31	Eq. 1	33.93	7.26	11.04	2.91	63.04	12.79^b
Human	3.00	2.51–3.52	Eq. 1	9.51	2.70	5.06	1.81	19.72	4.74^b
Cynomolgus Monkey	2.89	1.42–5.31	Eq. 2	3.32	2.64	2.90	1.90	3.43	2.97
Human	3.00	2.51–3.52	Eq. 2	2.81	1.83	2.37	1.48	3.16	2.32
Cynomolgus Monkey	2.89	1.42–5.31	Eq. 3	3.03	2.13	2.41	1.54	3.25	2.51
Human	3.00	2.51–3.52	Eq. 3	2.78	1.81	2.34	1.47	3.14	2.29

AUC, area under the concentration-time curve; CI, confidence interval; RIF, rifampin; RSV, rosuvastatin.
↵a Fold AUC change predicted using different methods or equations (see Materials and Methods).
↵b Calculated R-value using the approach recommended by US Food and Drug Administration and International Transporter Consortium.