TABLE 2

Pharmacokinetics of TRV130 (i.v.) in mice, rats, dogs, and cynomolgus monkeys

Species	Dose	AUC_last	Terminal Half-Life, t_1/2	Clearance	Vss
	mg/kg	hr•ng/ml	hr	l/kg/hr	l/kg
Mouse	0.3	35.9	2.45	8.27	4.5
Rat	0.5	70.8	0.8	6.97	6.9
Dog	0.5	992	3	0.64	0.51
Monkey	0.3	165	4.5	1.81	2.86

AUC_last, area under the concentration curve from time=0 to 8 hours (for rodents) and 24 hours (for dog and monkey); V_ss, volume at steady-state.