TABLE 2

Tumor/plasma ratios

Accumulation of P505-15 within the tumor is evidenced by ratios of greater than 1 at Cmin for each of the dose levels.

Dosing Regimen	Tumor/Plasma Ratio
Dosing Regimen	AUC Based	Cmax Based	Cmin Based
10 mg/kg BID	0.478	0.308	1.39
15 mg/kg BID	0.284	0.475	2.55
20 mg/kg BID	0.455	0.442	3.15