Contractile Agent/Relaxant | EPA | IPA | ||
---|---|---|---|---|
With Endothelium | Without Endothelium | With Endothelium | Without Endothelium | |
mN | ||||
ET-1/ACT-333679 | 8.9 ± 1.3 | 10.3 ± 1.1 | 3.5 ± 0.4 | 3.2 ± 0.3 |
ET-1/treprostinil | 8.1 ± 0.9 | 10.5 ± 1.0 | 2.7 ± 0.3 | 2.8 ± 0.3 |
Phenylephrine/ACT-333679 | 5.5 ± 0.8 | 7.6 ± 1.2 | 3.1 ± 0.2 | 2.8 ± 0.3 |
Phenylephrine/treprostinil | 6.5 ± 0.9 | 6.7 ± 0.5 | 3.1 ± 0.1 | 3.4 ± 0.2 |