Relaxant potency of ACT-333679 in rat pulmonary artery
| Contractile Agent | EPA | IPA | ||
|---|---|---|---|---|
| With Endothelium | Without Endothelium | With Endothelium | Without Endothelium | |
| pEC50 | ||||
| ET-1 | 5.0 ± 0.3 | 4.8 ± 0.3 | 5.4 ± 0.2 | 4.5 ± 0.2* |
| Phenylephrine | 4.9 ± 0.1 | 4.7 ± 0.1 | 5.1 ± 0.2 | 4.5 ± 0.1* |
↵* , P < 0.05, comparison between IPA with and without endothelium.